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Hepatotoxic side-effect of clomethiazole
1Department of Neurology, St-Josef-Hospital, Moers, Germany.
Pharmacopsychiatry
|September 1, 1996
Summary
Clomethiazole, used for alcoholic delirium, can cause hyperbilirubinemia and cholestasis. Discontinuing the drug improved the patient's symptoms, highlighting a potential adverse effect of this medication.
Area of Science:
- Pharmacology
- Hepatology
- Toxicology
Background:
- Clomethiazole is a sedative and anti-convulsive medication used in treating alcoholic delirium.
- It is a thiazole analogon, chemically related to thiamine (vitamin B1).
- Potential adverse effects require careful monitoring in patients undergoing treatment.