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Two monoclonal antibodies from the platelet panel recognize sheep plasma fibrinogen
J M Pérez de la Lastra1, A Mateo, R Dusinsky
1Departamento de Genética, Facultad de Veterinaria, Universidad de Córdoba, Spain.
Veterinary Immunology and Immunopathology
|August 1, 1996
Abstract:
Among the monoclonal antibodies (mAbs) submitted to the third Workshop, two mAbs, IVA120 (3W-323) and IVA198 (3W-290), could be identified to recognize the sheep fibrinogen molecule. The apparent molecular weight of the immunoprecipitated 48-60 kDa cell surface protein under reducing conditions suggested this antigen could be the fibrinogen molecule. ELISA and immunoblotting assays, performed with commercially available sheep plasma fibrinogen, confirmed that these two mAbs recognize two different epitopes present on the sheep fibrinogen molecule.