Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acquired chronic candidiasis treated with transfer factor

C C Benz, J W Thomas, M Mandl

    The British Journal of Dermatology
    |July 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands.

    Nature communications·2023
    Same author

    A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT.

    Cell death & disease·2016
    Same author

    TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer.

    Oncogene·2016
    Same author

    32nd International Austrian Winter Symposium : Zell am See, the Netherlands. 20-23 January 2016.

    EJNMMI research·2016
    Same author

    Genes located in a chromosomal inversion are correlated with territorial song in white-throated sparrows.

    Genes, brain, and behavior·2015
    Same author

    Importance of dispersal routes that minimize open-ocean movement to the genetic structure of island populations.

    Conservation biology : the journal of the Society for Conservation Biology·2015

    A patient with chronic candidiasis resistant to standard treatments showed immune deficiencies. Transfer factor therapy restored immune function and clinical remission for a year, highlighting its potential for treating resistant fungal infections.

    Area of Science:

    • Immunology
    • Mycology
    • Infectious Diseases

    Background:

    • Chronic mucocutaneous candidiasis can be associated with impaired cell-mediated immunity.
    • Acquired resistance to conventional antifungal therapies presents a significant clinical challenge.

    Observation:

    • A patient presented with chronic oral and vaginal candidiasis refractory to topical and parenteral treatments.
    • The patient exhibited impaired cell-mediated immunity to Candida antigen and a negative tuberculin skin test (Mantoux).

    Findings:

    • Treatment with Candida-active transfer factor led to a 1-year clinical remission.
    • Immune parameters, both in vitro and in vivo, were restored following transfer factor administration.
    • Relapse occurred upon re-administration of transfer factor from the same donor, suggesting potential donor-specific factors or waning immunity.

    Related Experiment Videos

  • Subsequent treatment with levamisole resulted in the development of agranulocytosis.

    • Implications:

    • Transfer factor therapy shows promise for managing complex and resistant cases of candidiasis by addressing underlying immune defects.
    • The study underscores the importance of assessing cell-mediated immunity in patients with chronic, refractory fungal infections.
    • Levamisole should be used with caution in immunocompromised patients due to potential severe adverse effects like agranulocytosis.