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Updated: Aug 15, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Serious infections due to penicillin-resistant Streptococcus peneumoniae in two children with nephrotic syndrome
Insights
Children with nephrotic syndrome face higher risks of invasive bacterial infections from Streptococcus pneumoniae. Penicillin-resistant strains are increasingly common, necessitating consideration of alternative initial therapies for these patients.
Area of Science:
- Pediatric Nephrology
- Infectious Diseases
- Bacteriology
Background:
- Children with nephrotic syndrome exhibit increased susceptibility to invasive bacterial infections.
- Streptococcus pneumoniae is a primary pathogen causing severe infections in this vulnerable group.
- Emerging resistance to penicillin in pneumococcal strains poses a growing public health concern.
Abstract:
Children with nephrotic syndrome are susceptible to the development of invasive bacterial infections, particularly those caused by Streptococcus peneumoniae. Recently, penicillin-resistant pneumococcal infections in children have occurred in increased frequency in some regions. We have seen two children with nephrotic syndrome who developed penicillin-resistant pneumococcal bacteremia and/or peritonitis. A change in the initial therapy from penicillin in the usual dose in these patients must be considered.
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