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Related Experiment Videos

Prematurity alters hypoxic and hypercapnic ventilatory responses in developing lambs

M G Davey1, T J Moss, G J McCrabb

  • 1Department of Physiology, Monash University, Melbourne, Victoria, Australia.

Respiration Physiology
|August 1, 1996
PubMed
Summary

Preterm birth impairs the development of breathing responses in lambs. Ventilatory responses to low oxygen (hypoxia) and high carbon dioxide (hypercapnia) mature differently after preterm birth compared to full-term birth.

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Area of Science:

  • Neonatal Physiology
  • Respiratory Control
  • Developmental Biology

Background:

  • Preterm birth can impact infant development.
  • Understanding ventilatory control is crucial for preterm infants.

Purpose of the Study:

  • To investigate the effects of preterm birth on the postnatal development of ventilatory responses to hypoxia and hypercapnia in lambs.

Main Methods:

  • Hypoxic and hypercapnic rebreathing tests were conducted weekly in preterm and term lambs.
  • Minute ventilation, arterial PO2, and PCO2 were measured.
  • Hypoxic sensitivity was defined as the % increase in ventilation when PaO2 reached 60% of resting values.

Main Results:

  • Preterm lambs showed unchanged hypoxic sensitivity with age.

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  • Term lambs exhibited a more than twofold increase in hypoxic sensitivity by 6 weeks postnatal.
  • Hypercapnic sensitivity was lower in preterm lambs initially but normalized later.

    • Conclusions:

    • Preterm birth disrupts the normal maturation of hypoxic ventilatory sensitivity.
    • Hypercapnic ventilatory sensitivity is temporarily reduced following preterm birth.