Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coronary hyperperfusion augments myocardial oxygen consumption

Y Ishibashi1, J Zhang, D J Duncker

  • 1Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA.

The American Journal of Physiology
|October 1, 1996
PubMed
Summary

Increases in myocardial oxygen consumption (MVo2) and contractile function during exercise are limited by coronary blood flow. This study in dogs suggests that enhancing blood flow improves MVo2 per beat and subepicardial thickening during exercise.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In-culture coronary stenting in an <i>ex vivo</i> vascular bioreactor.

Frontiers in cardiovascular medicine·2025
Same author

Induction of cardiac fibulin-4 protects against pressure overload-induced cardiac hypertrophy and heart failure.

Communications biology·2025
Same author

Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities.

Basic research in cardiology·2024
Same author

Questionnaire survey on cardiologists' view and management of coronary microvascular disease in clinical practice.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2019
Same author

Arginase - a novel target for cardioprotection by vagal nerve stimulation.

Acta physiologica (Oxford, England)·2017
Same author

CECR1-mediated cross talk between macrophages and vascular mural cells promotes neovascularization in malignant glioma.

Oncogene·2017

Area of Science:

  • Cardiovascular Physiology
  • Exercise Physiology
  • Myocardial Metabolism

Background:

  • Myocardial oxygen consumption (MVo2) and contractile function increase during exercise.
  • The extent to which these increases are limited by coronary blood flow is not fully understood.

Purpose of the Study:

  • To test the hypothesis that increases in MVo2 and myocardial contractile function during exercise are flow-limited.
  • To investigate the effects of maximal vasodilation on myocardial function and oxygen use during graded exercise.

Main Methods:

  • Studies were conducted in 15 instrumented normal dogs.
  • Myocardial oxygen consumption (MVo2) and systolic wall thickening were measured.
  • Maximal vasodilation was achieved using adenosine or adenosine with nitroglycerin (TNG) infusion into the left anterior descending coronary artery during treadmill exercise.

Related Experiment Videos

Main Results:

  • Adenosine and adenosine plus TNG significantly increased coronary blood flow at rest and during exercise.
  • MVo2 per beat and subepicardial wall thickening increased significantly during moderate and heavy exercise with hyperperfusion.
  • No significant changes in MVo2 per beat or overall wall thickening were observed at rest.

Conclusions:

  • Increases in myocardial oxygen consumption during exercise are limited by coronary blood flow.
  • Enhanced coronary blood flow improves myocardial oxygen consumption per beat and regional contractile function, particularly in the subepicardial layer, during exercise.