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Economic evaluation in gastrointestinal disease

B Jönsson1, G Karlsson

  • 1Stockholm School of Economics, Dept. of Economics, Sweden.

Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1996
PubMed
Summary

Economic evaluations show omeprazole is more cost-effective than ranitidine for reflux esophagitis. Helicobacter pylori eradication is also cost-effective for duodenal ulcers, reducing long-term costs and relapses.

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Area of Science:

  • Health Economics
  • Gastroenterology
  • Pharmacoeconomics

Background:

  • Medical technology choices increasingly consider cost-effectiveness alongside safety and efficacy.
  • Economic evaluation methods like cost-effectiveness, cost-utility, and cost-benefit analysis are crucial for assessing value for money in healthcare.
  • Ulcer disease management provides practical examples for applying economic evaluations to healthcare efficiency.

Purpose of the Study:

  • To compare the cost-effectiveness of omeprazole versus ranitidine for reflux esophagitis.
  • To evaluate the cost-effectiveness of Helicobacter pylori eradication compared to conventional treatments for duodenal ulcer disease.

Main Methods:

  • Cost-effectiveness analysis using a Markov chain model.
  • Inclusion of Swedish cost data and a 12-month time horizon for reflux esophagitis.
  • Inclusion of Swedish cost data and a 5-year time horizon for duodenal ulcer disease, comparing H. pylori eradication with episodic and maintenance therapies.

Main Results:

  • Omeprazole demonstrated superior cost-effectiveness over ranitidine for both intermittent and maintenance treatment of reflux esophagitis, offering better outcomes at lower costs.
  • Helicobacter pylori eradication was found to be more cost-effective than episodic or maintenance therapies for duodenal ulcers, despite higher initial costs.
  • H. pylori eradication significantly reduced relapse rates, leading to no future costs for most patients and a rapid pay-off period.

Conclusions:

  • Omeprazole represents a more cost-effective treatment option for reflux esophagitis compared to ranitidine.
  • Helicobacter pylori eradication is a cost-effective strategy for duodenal ulcer disease, offering long-term benefits and reduced recurrence.
  • The economic advantages of H. pylori eradication become more pronounced with higher relapse risks and greater value placed on symptom-free days.

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