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Resistance to activated protein C (APC) in Indian patients of thrombophilia
H P Pati1, A Srivastava, S Dayal
1Department of Haematology, All India Institute of Medical Sciences, New Delhi.
The Indian Journal of Medical Research
|September 1, 1996
Abstract:
In a pilot study, 28 consecutive patients with thrombosis and 23 age and sex matched healthy normal controls were investigated with normalised APC sensitivity ratio (n-APC-SR) to know the defect exists and if so its prevalence in India. Six of the 28 (21.4%) thrombotic patients had n-APC-SR of < 0.76 (range 0.55 to 0.74) as compared to the normal control value (0.97 +/- 0.105). Our study shows APC resistance defect in a significant proportion (21.4%) of Indian patients with thrombotic disorders.