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Related Experiment Videos

Does rectal examination affect serum acid phosphatase levels?

S K Bannerjee, I F Barker, T A Waterworth

    The British Journal of Surgery
    |July 1, 1979
    PubMed
    Summary

    Digital rectal examination does not affect serum acid phosphatase (SAP) levels. Blood tests for SAP can be reliably performed within 48 hours after this common prostate examination.

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    Area of Science:

    • Urology
    • Clinical Chemistry

    Background:

    • Serum acid phosphatase (SAP) is a biomarker often evaluated in patients with symptoms of prostatism.
    • Digital rectal examination (DRE) is a standard diagnostic procedure for prostate conditions.
    • There is a prevailing belief that DRE may elevate SAP levels, potentially impacting diagnostic accuracy.

    Purpose of the Study:

    • To investigate the effect of digital rectal examination (DRE) on serum acid phosphatase (SAP) levels.
    • To determine the reliability of SAP measurements within a 48-hour period following DRE.

    Main Methods:

    • Formol-stable serum acid phosphatase (SAP) was measured in 200 patients presenting with symptoms of prostatism.
    • Patients were divided into four groups, with SAP levels assessed before and at various intervals (5, 15, 30 minutes and 6, 24, 48 hours) after DRE.

    Main Results:

    • No statistically significant changes in SAP levels were observed at any of the measured time points following DRE across all patient groups.
    • The findings indicate that DRE does not induce a rise in serum acid phosphatase.

    Conclusions:

    • Digital rectal examination does not alter serum acid phosphatase levels.
    • SAP blood test results are reliable for diagnostic purposes within 48 hours after DRE, challenging prior assumptions.

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