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Platelet-derived growth factor A and B chains and the alpha and beta receptors in prostatic intraepithelial neoplasia
K Fudge1, D G Bostwick, M E Stearns
1Department of Pathology, Medical College of Pennsylvania, Philadelphia 19129, USA.
Background:
The objective of this study was to evaluate the expression of platelet-derived growth factor (PDGF A, PDGF B) and their receptors (PDGF alpha, PDGF beta) in prostatic intraepithelial neoplasia (PIN) and adenocarcinoma.
Methods:
Peroxidase-antiperoxidase immunoperoxidase labeling was used to detect the extent of antibody labeling in 29 different high grade PIN specimens.
Results:
PDGF A and PDGF alpha were uniformly expressed in glandular epithelial and stromal cells, whereas PDGF B was not expressed by either tissue. However, PDGF beta was lightly expressed in a uniform manner by both the glandular epithelial and stromal cells.
Conclusions:
The data suggest that an autocrine loop may exist in which the epithelial cells of high-grade PIN express PDGF AA and PDGF alpha to modulate growth of precancerous lesions.