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Serum alpha 1-antitrypsin concentration in dogs with panniculitis
D Hughes1, M H Goldschmidt, R J Washabau
1Center for Veterinary Critical Care, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.
Objective:
To measure serum alpha 1-antitrypsin (alpha 1AT) concentration in dogs with histologically confirmed panniculitis to determine whether serum deficiency could cause or exacerbate panniculitis in dogs.
Design:
Cross-sectional, descriptive study.
Animals:
9 dogs (5 with multiple lesions and 4 with solitary lesions).
Procedure:
Serum samples were obtained by means of cephalic or jugular venipuncture and frozen at -20 C until assayed. Serum alpha 1AT concentration was measured by means of radial gel immunodiffusion.
Results:
In all dogs, serum alpha 1AT concentration was within the previously established reference range.
Clinical Implications:
In the small number of-dogs studied, panniculitis was not associated with serum alpha 1AT deficiency.
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