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Conflict situation increases serotonin release in rat dorsal hippocampus: in vivo study with microdialysis and Vogel
M Matsuo1, Y Kataoka, S Mataki
1Department of Dental Anesthesiology, Nagasaki University Dental Hospital, Japan.
Neuroscience Letters
|September 13, 1996
Abstract:
The release of serotonin (5-hydroxytryptamine, 5-HT) in the dorsal hippocampus was measured using an in vivo microdialysis method in rats subjected to the Vogel type conflict test. The conflict situation significantly increased 5-HT release in the dorsal hippocampus. Midazolam (0.75 and 1.5 mg/kg i.p.) suppressed the dosage-dependently this increased 5-HT release, an inhibition closely associated with the attenuation of conflict behavior. These findings suggest that the activation of serotonergic neuronal activity in the dorsal hippocampus is linked to mediation of anxiety-related behavior.