Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydrotropic solubilization--mechanistic studies

R E Coffman1, D O Kildsig

  • 1Purdue University, West Lafayette, Indiana 47907, USA.

Pharmaceutical Research
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of hydrodynamic environment on tablets dissolution rate.

Pharmaceutical development and technology·2004
Same author

An examination of the moisture sorption characteristics of commercial magnesium stearate.

AAPS PharmSciTech·2004
Same author

Prediction of tablet hardness and porosity using near-infrared diffuse reflectance spectroscopy as a nondestructive method.

Pharmaceutical development and technology·2003
Same author

Relationship between internal phase volume and emulsion stability: the cetyl alcohol/stearyl alcohol system.

Pharmaceutical development and technology·2003
Same author

The effect of particle morphology on the physical stability of pharmaceutical powder mixtures: the effect of surface roughness of the carrier on the stability of ordered mixtures.

Drug development and industrial pharmacy·2000
Same author

Effect of nicotinamide and urea on the solubility of riboflavin in various solvents.

Journal of pharmaceutical sciences·1996
Same journal

Leveraging Carnitine-functionalized Lipid Nanocarrier based Targeted Delivery of A1874 PROTAC for Glioblastoma.

Pharmaceutical research·2026
Same journal

Impact of Febrile State on Vancomycin Clearance in Pediatric Patients: Insights From Population Pharmacokinetic Modeling.

Pharmaceutical research·2026
Same journal

Sustained Intra-Articular Delivery of Triple Therapeutics Using a Phase-Transition Phospholipid-Based Gel for Effective Treatment of Gouty Arthritis.

Pharmaceutical research·2026
Same journal

Spray Dried Lysozyme Microspheres: Morphological Evolution and Enzymatic Activity Retention.

Pharmaceutical research·2026
Same journal

Colloidal Stability of Amorphous Nanoparticles in Solution: Impact of Stabilizer.

Pharmaceutical research·2026
Same journal

Impact of Mixing Approach and Bubble Formation on In Situ Forming Implant Properties.

Pharmaceutical research·2026
See all related articles

Hydrotropic solubilization of riboflavin by nicotinamide does not involve complexation. Instead, nicotinamide self-association, which decreases with increasing temperature, is key to its hydrotropic ability.

Area of Science:

  • Physical Chemistry
  • Pharmaceutical Sciences

Background:

  • Hydrotropic solubilization enhances the solubility of poorly soluble compounds.
  • The riboflavin-nicotinamide system is a model for studying hydrotropic mechanisms.
  • Complexation and self-association are proposed mechanisms for hydrotropic agents.

Purpose of the Study:

  • To investigate the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system.
  • To determine if complexation between riboflavin and nicotinamide is the primary mechanism.
  • To assess the role of nicotinamide self-association in hydrotropic ability by examining temperature effects.

Main Methods:

  • Tested complexation by measuring riboflavin fluorescence quenching and UV/Vis spectral changes upon nicotinamide addition.
  • Determined riboflavin solubility in nicotinamide solutions at varying temperatures to evaluate the impact of self-association.

Related Experiment Videos

Main Results:

  • Nicotinamide did not quench riboflavin fluorescence, and no significant spectral changes indicating complexation were observed.
  • Increasing temperature decreased the solubilizing capacity of nicotinamide, indicating temperature dependence of hydrotropic ability.

Conclusions:

  • Complexation between riboflavin and nicotinamide is not the mechanism of hydrotropic solubilization.
  • The temperature-dependent decrease in nicotinamide's hydrotropic ability suggests that nicotinamide self-association plays a significant role in the mechanism.