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Methotrexate and misoprostol for early abortion
E A Schaff1, S H Eisinger, P Franks
1Department of Family Medicine, University of Rochester, NY, USA.
Family Medicine
|March 1, 1996
Summary
Medical abortion using methotrexate and misoprostol is effective for early pregnancies, offering a safe alternative to surgical procedures with high patient satisfaction and manageable side effects.
Area of Science:
- Reproductive Medicine
- Pharmacology
Background:
- Medical abortion offers an alternative to surgical procedures.
- Methotrexate and misoprostol are commonly used for medical abortion.
Purpose of the Study:
- To evaluate the effectiveness of medical abortion using methotrexate and misoprostol.
- To assess side effects, patient satisfaction, and optimal treatment strategies.
Main Methods:
- Prospective trial of women with gestation ≤ 8 weeks.
- Intramuscular methotrexate followed by oral or vaginal misoprostol.
- Repeat misoprostol doses administered if necessary; surgical abortion for continuing pregnancies.
Main Results:
- 97% of subjects (274/282) achieved medical abortion.
- Vaginal misoprostol was more effective than oral.
- Mild gastrointestinal side effects were common; 88% reported positive procedure experience.
Conclusions:
- Methotrexate and misoprostol are effective for abortion up to 8 weeks' gestation.
- This medical regimen is a viable alternative to surgical abortion.