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Decreased expression of HSP47 in highly malignant mouse fibrosarcoma
T Shirakami1, T Tsuzuki, M Morino
1Senior Research Fellow Laboratory, Kureha Chemical Industry, Co., Ltd., Tokyo, Japan.
In Vivo (Athens, Greece)
|September 1, 1995
Abstract:
HSP47, a heat shock-inducible glycoprotein of M(r) = 47,000, is assumed to be a molecular chaperone specific for collagen. In addition to its stress inducibility, HSP47 has transformation-sensitivity; that is, the synthesis of HSP47 decreases after malignant transformation. The expression of several HSPs in mouse fibrosarcoma, QRsP-1 and QRsP-4 were examined. HSP47 expression was weaker in the highly malignant QRsP-4 than in the weakly malignant QRsP-1, whilst HSC70 expression was similar in both cell lines. These findings suggested an important role of HSP47 as a marker of tumour malignancy of QRsP cell lines.