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Importance of the carboxy-terminus of human interleukin-11 in conserving its biological activity
K Miyadai1, J Ohsumi, C Yoshimura
1Biomedical Research Laboratories, Sankyo Co. Ltd., Tokyo, Japan.
Biological activities of the carboxy-terminal (C-terminal) deletion mutants of human interleukin-11 (IL-11) were analyzed. Removal of only 1 amino-acid residue (leucine) from the C-terminus caused nearly an 80% loss of its biological activity. This shows the importance of C-terminus of human IL-11 in terms of conserving the biological activity.
Biological activities of the carboxy-terminal (C-terminal) deletion mutants of human interleukin-11 (IL-11) were analyzed. Removal of only 1 amino-acid residue (leucine) from the C-terminus caused nearly an 80% loss of its biological activity. This shows the importance of C-terminus of human IL-11 in terms of conserving the biological activity.