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Synthesis and quantitative structure-activity relationships of antihyperlipaemic 2-substituted
C J Shishoo1, K S Jain, I S Rathod
1L. M. College of Pharmacy, Ahmedabad, India.
Arzneimittel-Forschung
|March 1, 1996
Abstract:
The synthesis, antihyperlipaemic evaluation and quantitative structure-activity relationships (QSAR) of two series of thieno[3,2-d]pyrimidin-4-one derivatives are reported. While most of the compounds in these series were found to exhibit antihyperlipaemic activity, the QSAR study of these two series indicated a positive influence of only the electronic nature of the 2-substitutents on the biological activity. The lipophilic and the steric parameters did not appear to be significant.