[Role of prostaglandin endoperoxides in thrombocyte aggregation]

Phospholipase A and lysolecithin stimulated the thromboplastic factor release reaction and the red blood cells and platelets aggregation. According to polarographic research data, these aggregating agents brought about oxygen consumption in the platelet-containing medium. In all probability, this indicated that endoperoxides, an intermediate product of prostaglandin synthesis, were created under the mentioned conditions. Albumin failed to prevent the oxygen release reaction and its consumption, provoked by phospholipase A and lysolecithin, but totally inhibited their aggregation capacity. On the contrary, aspirin, blocked the oxygen consumption by platelets, without producing any significant effect on the lysolecithin aggregation capacity. It is assumed that the blood formed elements aggregation is due to perturbation of their membrane lipid-protein structure, and not to the endoperoxide synthesis.