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Histological response to stent graft therapy
1Department of Surgery, University of Illinois at Chicago, USA.
Circulation
|November 1, 1996
Summary
Stent graft technology successfully excluded blood flow in canine abdominal aortic dilation (AAD), preventing further dilation. Histology revealed a collagen-rich neointima incorporating the graft, despite some thrombus recanalization.
Area of Science:
- Vascular surgery
- Biomaterials science
- Histopathology
Background:
- Endoluminal exclusion of blood flow using stent graft technology is a novel approach.
- Abdominal aortic dilation (AAD) models in canines provide insights into vascular repair mechanisms.
Purpose of the Study:
- To investigate the histological outcomes of endoluminal blood flow exclusion using stent graft technology in a canine model of abdominal aortic dilation.
- To assess the long-term effects of stent graft incorporation and neointimal formation.
Main Methods:
- Mongrel dogs underwent infrarenal aortoplasty with a vein patch, creating abdominal aortic dilation (AAD).
- Transfemoral placement of a Dacron stent graft was performed 4 months later.
- Histological analysis (H&E, EVG, Masson's trichrome) was conducted at 6 and 12 months post-stent graft placement.
Main Results:
- Stent grafts were fully incorporated into a collagen-rich, elastin-poor neointima within 6-12 months.
- Laminated thrombus formed after stent graft placement, with microscopic recanalization observed at 12 months.
- No significant AAD growth was noted, and vein patch fibrosis occurred by 1 year.
Conclusions:
- Stent graft placement effectively stabilized AADs with patent side branches, preventing further dilation.
- The neointima formed around the stent graft was characterized by high collagen and low elastin content.
- Microscopic thrombus recanalization did not impede the overall success of the endovascular repair.