Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Three-dimensional extracellular matrix textured biomaterials

S L Goodman1, P A Sims, R M Albrecht

  • 1Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706, USA.

Biomaterials
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-tissue immune cell analysis reveals tissue-specific features in humans.

Science (New York, N.Y.)·2022
Same author

Prehospital needle thoracostomy: What are the indications and is a post-trauma center arrival chest tube required?

American journal of surgery·2019
Same author

Immuno-EM using colloidal metal nanoparticles and electron spectroscopic imaging for co-localization at high spatial resolution.

Journal of microscopy·2008
Same author

Distinctive role of integrin-mediated adhesion in TNF-induced PKB/Akt and NF-kappaB activation and endothelial cell survival.

Oncogene·2007
Same author

Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro.

Histopathology·2004
Same author

RGD-mutants of B-lymphotropic polyomavirus capsids specifically bind to alpha(v)beta3 integrin.

Archives of virology·2004
Same journal

A sonosensitizing hydrogel with tumour-confined stability for intrinsically targeted sonodynamic therapy.

Biomaterials·2026
Same journal

Multidimensional intestinal barrier repair strategies for alleviating inflammatory bowel disease and gut-liver axis-associated metabolic liver disease.

Biomaterials·2026
Same journal

A dual-twisted molecular strategy achieves dramatic quantum-yield enhancement in NIR-II AIEgen for high-performance bioimaging.

Biomaterials·2026
Same journal

An oxygen-glucose co-releasing platform fostering dental pulp regeneration by driving metabolic recovery of stem cells.

Biomaterials·2026
Same journal

Prodrug-decorated 2D hafnium sulfide nanoplatelets as "amplify-and-arrest" platforms for radiosensitization and homologous recombinant inhibition in solid tumor.

Biomaterials·2026
Same journal

In-situ cascade assembled peptide-drug conjugate for the treatment of bladder cancer by enhancing membrane-entry and lysosome destabilization.

Biomaterials·2026
See all related articles

Researchers created biomimetic surfaces mimicking the extracellular matrix (ECM) topography. These surfaces improved endothelial cell adhesion and spreading, offering potential for tissue engineering and regenerative medicine applications.

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • Manufactured surface topographies influence cell adhesion and tissue integration.
  • Existing topographies poorly mimic the complex 3D extracellular matrix (ECM) found in tissues.
  • Cellular responses are affected by micro/nano-scale mechanical stresses from cell-matrix interactions.

Purpose of the Study:

  • To develop a methodology for fabricating topographic replicas of subendothelial ECM.
  • To evaluate the effect of these biomimetic surfaces on endothelial cell behavior.
  • To assess the potential of these surfaces for biomedical applications.

Main Methods:

  • Fabrication of ECM topographic replicas using biomedical polyurethane.
  • High-resolution 3D scanning electron microscopy for topography verification.

Related Experiment Videos

  • Culturing bovine aortic endothelial cells on fabricated ECM replicas and control surfaces.

    • Main Results:

    • Accurate replication of subendothelial ECM topography from macro to molecular scales was achieved.
    • Endothelial cells cultured on ECM replicas exhibited faster spreading and a more native 3D morphology.
    • Cells on biomimetic surfaces showed improved spread areas at confluence compared to controls.

    Conclusions:

    • Biomimetic ECM-textured surfaces can be fabricated with high fidelity.
    • These surfaces enhance endothelial cell adhesion, spreading, and morphology.
    • The fabrication method's versatility suggests broad research and clinical applications in biomaterials and regenerative medicine.