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Updated: Aug 8, 2026
07:51
The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
Published on: November 4, 2010
Summary
Patients with anal fissure exhibit higher internal anal sphincter pressure and abnormal ultra-slow waves. Both dilatation and lateral subcutaneous sphincterotomy effectively correct this abnormal internal sphincter activity.
Area of Science:
- Gastroenterology
- Colorectal Surgery
Background:
- Anal fissure is a common condition often associated with increased anal sphincter tone.
- Understanding the pathophysiology of internal anal sphincter (IAS) dysfunction is crucial for effective treatment.
Purpose of the Study:
- To investigate the activity of the internal anal sphincter in patients with anal fissure.
- To compare IAS pressure and motility in patients with fissure versus healthy controls.
Main Methods:
- Anal pressure and motility were measured using a small balloon probe.
- Evaluated 12 patients with anal fissure and 40 healthy control subjects.
Main Results:
- Patients with anal fissure showed significantly higher mean maximum anal pressure (116.8 cm H2O) compared to controls (85.0 cm H2O).
- Ultra-slow pressure waves, indicative of abnormal IAS activity, were present in 80% of patients versus 5% of controls.
- High pressure and ultra-slow waves were attributed to abnormal IAS activity.
Conclusions:
- Abnormal internal anal sphincter activity, characterized by high pressure and ultra-slow waves, is a key feature in patients with anal fissure.
- Both anal dilatation and lateral subcutaneous sphincterotomy are effective treatments for correcting IAS abnormalities in anal fissure.
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