Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microencapsulation reactor scale-up by dimensional analysis

Y F Maa1, C Hsu

  • 1Department of Pharmaceutical Research and Development, Genentech, Inc., South San Francisco, CA 94080, USA.

Journal of Microencapsulation
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of CFRD development among females with CF who use hormonal contraception.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same author

Corrigendum to "Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with biliary tract cancer": [ESMO Open 9 (2024) 103647].

ESMO open·2025
Same author

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with biliary tract cancer.

ESMO open·2024
Same author

Evidence of an Off-Resonant Electronic Transport Mechanism in Helicenes.

The journal of physical chemistry letters·2024
Same author

Nivolumab plus ipilimumab combination therapy in patients with advanced hepatocellular carcinoma previously treated with sorafenib: 5-year results from CheckMate 040.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Nivolumab in sorafenib-naive and sorafenib-experienced patients with advanced hepatocellular carcinoma: 5-year follow-up from CheckMate 040.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same journal

Rationally engineered essential oil-loaded nanocarriers for acne vulgaris: integrating multiscale molecular modeling, machine learning, and response surface optimization.

Journal of microencapsulation·2026
Same journal

Retinyl palmitate-loaded nanostructured lipid carriers prepared by the phase inversion temperature method: Physicochemical properties, <i>in vitro</i> skin permeation, and occlusion ability.

Journal of microencapsulation·2026
Same journal

Green synthesis of silver nanoparticles using <i>Swertia chirayita</i> and their antioxidant and anticancer potential.

Journal of microencapsulation·2026
Same journal

Management of coronary artery disease via simvastatin-loaded novasomes.

Journal of microencapsulation·2026
Same journal

Phyto-engineered CuO nanoparticles from gum <i>Eucalyptus camaldulensis</i>: a GC-MS, molecular docking, and bioactivity study.

Journal of microencapsulation·2026
Same journal

Development and optimization of gallic acid-enriched nanostructured lipid carriers for the amelioration of rheumatic inflammation: <i>in-vitro</i> and <i>in-vivo</i> study.

Journal of microencapsulation·2026
See all related articles

This study scaled up protein microsphere production using a solvent-extraction method in continuously stirred tank reactors (CSTR). Dimensional analysis enabled predictable control over microsphere size during large-scale manufacturing.

Area of Science:

  • Chemical Engineering
  • Materials Science
  • Pharmaceutical Technology

Background:

  • Microencapsulation is crucial for drug delivery and controlled release applications.
  • Scaling up microencapsulation processes from laboratory to industrial volumes presents significant challenges in maintaining particle characteristics.
  • Solvent-extraction methods are widely used but require careful optimization for reproducible results at larger scales.

Purpose of the Study:

  • To develop a quantitative correlation for predicting microsphere size during the scale-up of a solvent-extraction microencapsulation process.
  • To investigate the relationship between process parameters and microsphere size in continuously stirred tank reactors (CSTRs).
  • To validate the developed correlation for both protein-free and protein-loaded microsphere systems.

Related Experiment Videos

Main Methods:

  • Scale-up of a solvent-extraction microencapsulation process from 1 L to 100 L batch sizes using CSTRs.
  • Application of dimensional analysis to establish a correlation between microsphere size and process parameters.
  • Utilized protein-free poly(lactic acid-co-glycolic acid) microspheres in an oil-in-water emulsion for initial correlation development.
  • Investigated poly(methyl methacrylate) as a model polymer for scale-up studies.

Main Results:

  • A quantitative correlation was successfully established between microsphere size and key process parameters.
  • The developed correlation accurately predicted microsphere size for both protein-free and protein-loaded systems.
  • Poly(methyl methacrylate) demonstrated similar behavior to poly(lactic acid-co-glycolic acid), confirming its utility as a model polymer.
  • The process was predictably scaled up to 100 L, yielding particles of defined sizes.

Conclusions:

  • Dimensional analysis is a powerful tool for predictably scaling microencapsulation processes.
  • The established correlation allows for precise control over microsphere size during large-scale production.
  • This work facilitates the efficient and reproducible manufacturing of protein-loaded microspheres for various applications.