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Related Experiment Videos

Decrease in plasma volume from intra-abdominal trauma in rats is prevented by H1 but not by H2 histaminergic blockade

M Larmark1, B Lisander

  • 1Department of Anaesthesiology and Intensive Care, University Hospital, Linkoping, Sweden.

Acta Anaesthesiologica Scandinavica
|January 1, 1996
PubMed
Summary

Intra-abdominal trauma causes plasma loss, which is prevented by blocking H1 histamine receptors. This suggests H1 receptors play a key role in plasma extravasation following surgery.

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Area of Science:

  • Physiology
  • Pharmacology

Background:

  • Intra-abdominal surgery can lead to plasma extravasation.
  • Combined histaminergic H1 and H2 blockade prevents this effect in rats.

Purpose of the Study:

  • To evaluate the relative importance of H1 and H2 blockade in preventing plasma extravasation after abdominal trauma.

Main Methods:

  • Wistar rats underwent standardized abdominal trauma under anesthesia.
  • Mean arterial pressure, heart rate, and hematocrit were monitored.
  • Plasma volume was measured before and after trauma.

Main Results:

  • Trauma decreased plasma volume and increased hematocrit.
  • H2 blockade (cimetidine) had no significant effect.

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  • H1 blockade (pyrilamine) completely prevented plasma volume loss and hematocrit increase.

    • Conclusions:

    • Histaminergic H1 mechanisms are crucial for plasma loss following intra-abdominal trauma.
    • H1 receptor blockade is effective in mitigating plasma extravasation.