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Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man
N C Sambol1, L G Brookes, J Chiang
1Department of Biopharmaceutical Sciences, University of California, San Francisco 94143-0446, USA.
British Journal of Clinical Pharmacology
|October 1, 1996
Abstract:
The pharmacokinetics of four single-dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet formulations are bioequivalent. Bioavailability of a 500 mg tablet is 14% greater than that of an 850 mg tablet. Compared with the fasting state, bioavailability is 24% lower, and the peak concentration delayed about 37 min when an 850 mg tablet is administered with food.