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Effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine in normal man
T C Li Kam Wa1, S Freestone, J L McCrindle
1Department of Medicine, Royal Infirmary, Edinburgh, UK.
Abstract:
The effects of frusemide on the urinary excretion of dopamine and 5-hydroxytryptamine (5-HT) were investigated in eight healthy male subjects in a randomized, placebo-controlled, cross-over study. Frusemide produced the expected rise in urinary dopamine excretion but it did not affect 5-HT excretion when compared with placebo. The lack of an effect on 5-HT excretion in man contrasts with studies in the rat which have reported a marked increase in 5-HT excretion after administration of this loop diuretic.
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