Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigen presentation in the intestine

A Panja1, L Mayer

  • 1Mount Sinai Hospital, NY 10029, USA.

Bailliere'S Clinical Gastroenterology
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunogenicities of vaccines including the immunoglobulin M-degrading enzyme of <i>Streptococcus suis</i>, rIde <sub></sub> , and protective efficacy against serotype 14 in piglets.

Vaccine: X·2024
Same author

Effect of 5 weeks of oral acetazolamide on patients with pulmonary vascular disease: A randomized, double-blind, cross-over trial.

Pulmonology·2023
Same author

TEMPus VoLA: The timed Epstein multi-pressure vessel at low accelerations.

The Review of scientific instruments·2022
Same author

Survival patterns of Streptococcus suis serotypes 1 and 14 in porcine blood indicate cross-reactive bactericidal antibodies in naturally infected pigs.

Veterinary microbiology·2021
Same author

[Suicide stigma and suicide prevention].

Der Nervenarzt·2020
Same author

BedMachine v3: Complete Bed Topography and Ocean Bathymetry Mapping of Greenland From Multibeam Echo Sounding Combined With Mass Conservation.

Geophysical research letters·2017

The intestinal mucosa requires specialized immune defenses due to constant antigen exposure. Understanding antigen presentation by diverse antigen-presenting cells (APCs) is key to intestinal immune homeostasis.

Area of Science:

  • Immunology
  • Gastroenterology
  • Cell Biology

Background:

  • The intestinal mucosa is a large surface area constantly exposed to antigens.
  • Intestinal immune cells, like intraepithelial lymphocytes (IELs) and lymphocytes of the lamina propria (LPLs), function differently than those in peripheral organs.
  • The immune response in the gut is critical for maintaining homeostasis.

Purpose of the Study:

  • To investigate the mechanisms of antigen uptake, processing, and presentation in the intestine.
  • To understand the distinct roles of various antigen-presenting cells (APCs) in the intestinal mucosa.
  • To elucidate the differential functions of professional and non-professional APCs in intestinal immunity.

Main Methods:

  • The study discusses the need for in vivo model systems to study intestinal immune responses.

Related Experiment Videos

  • It highlights the importance of characterizing antigen handling and presentation by different APC subpopulations.
  • The research focuses on the distribution of responsibilities between professional and non-professional APCs.

    • Main Results:

    • The precise mechanisms of intestinal immune reactions are not fully understood.
    • Differential antigen handling and presentation by APCs in the gut are not well-characterized.
    • There is evidence suggesting non-professional APCs may play a dominant role in intestinal immunity.

    Conclusions:

    • Further research and development of in vivo models are needed to understand intestinal immune responses.
    • Characterizing APC diversity is essential for maintaining intestinal homeostasis.
    • A clearer understanding of antigen presentation in the gut will advance the field of intestinal immunology.