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Sparteine metabolism in a Nigerian population
J C Ritchie1, S C Mitchell, R L Smith
1Imperial College School of Medicine at St. Mary's, London, U.K.
Drug Metabolism and Drug Interactions
|January 1, 1996
Abstract:
The oxidative metabolism of sparteine has been investigated in a Nigerian population. The distribution of metabolic capacities was shown to be skewed with two subjects (2/97, 2.1%) being relatively deficient in their ability to produce the dehydrometabolites. These observations afford evidence that sparteine oxidation is under polymorphic control in Nigerians.