Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ischaemic preconditioning and cardiac surgery

A M Alkhulaifi1, D P Jenkins, W B Pugsley

  • 1Harefield Hospital, Middlesex, UK.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An unusual "internal" penetrating liver injury.

BMJ case reports·2025
Same author

SABR-5 Results Are Not Reliable in Assessing Improvement or Maintenance of Quality of Life Without Comparable Evaluation in Control Patients.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Stereotactic Ablative Radiotherapy for Oligometastatic Disease: Great Enthusiasm but Scant Evidence.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

NICE Guidelines: management of colorectal cancer metastases.

The British journal of surgery·2020
Same author

Pulmonary Metastasectomy in Colorectal Cancer: updated analysis of 93 randomized patients - control survival is much better than previously assumed.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same author

Local treatment of 'Oligometastases': Wishful thinking is not supported by available evidence.

Clinical oncology (Royal College of Radiologists (Great Britain))·2020
Same journal

Corrigendum to: Colchicine prevents perioperative myocardial injury in cardiac surgery by inhibiting the formation of neutrophil extracellular traps: evidence from rat models.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Mitral valve anomalies in transposition of the great arteries.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Oncologic Safety of Omitting Mediastinal Lymph Node Dissection in Segmentectomy for Ground-Glass Opacity-Dominant Lung Cancer: A Supplementary Analysis of JCOG1211.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Progress in Thymic Malignancy Care: The Imperative for Global Standards and Collaboration.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Association between interventional cardiologist practice characteristics, CABG use, and clinical outcomes.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

The EACTS Innovation Committee's Perspective on the "Heart Valve of the Future".

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
See all related articles

Ischaemic preconditioning protects the heart from injury by brief ischaemia. Evidence suggests the human heart can be preconditioned, but more cardiac surgery trials are needed.

Area of Science:

  • Cardiology
  • Physiology
  • Biochemistry

Background:

  • Ischaemic preconditioning is a biological phenomenon where brief periods of ischemia protect the heart from subsequent, more severe ischemic insults.
  • This adaptation delays myocardial necrosis and has been observed across multiple species.

Purpose of the Study:

  • To review the phenomenon of ischaemic preconditioning.
  • To discuss its potential application in cardiac surgery.
  • To examine the evidence for preconditioning in the human heart.

Main Methods:

  • Review of existing literature on ischaemic preconditioning.
  • Analysis of studies on myocardial infarction and percutaneous transluminal angioplasty in humans.
  • Examination of data from patients undergoing coronary artery bypass grafting with preconditioning protocols.

Related Experiment Videos

Main Results:

  • Ischaemic preconditioning delays myocardial necrosis, with 5 minutes of ischemia initiating protection for 1-2 hours.
  • Adenosine receptor stimulation initiates preconditioning via protein kinase C and ATP-dependent potassium channels.
  • Evidence suggests human hearts can be preconditioned, observed in angina patients, angioplasty procedures, and bypass surgery patients.

Conclusions:

  • Ischaemic preconditioning is a potent method for protecting the myocardium against irreversible ischemic injury.
  • There is growing evidence that the human heart exhibits preconditioning properties.
  • Further clinical trials in cardiac surgery are required to fully assess the role of preconditioning in myocardial protection.