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EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice

R J Buchsbaum1, J A Fabry, J Lieberman

  • 1Department of Medicine, New England Medical Center, Boston, MA, USA.

Immunology Letters
|September 1, 1996
PubMed

Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing human lymphoproliferative disease. CTL protection required a single dose of polyethylene-glycol-conjugated IL2. Mice were not protected by CTL that did not specifically recognize EBV-transformed B cells or by mitogen-activated lymphocytes.

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