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Malignant hyperthermia and althesin

N Honda, K Konno, Y Itohda

    Canadian Anaesthetists' Society Journal
    |July 1, 1977
    PubMed
    Summary
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    Althesin appears safe for patients susceptible to malignant hyperthermia, even with accidental or intentional exposure to other anesthetics. This study suggests Althesin can prevent hyperthermia in high-risk individuals.

    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Malignant hyperthermia (MH) is a severe, unpredictable reaction to certain anesthetic agents.
    • Patients with myopathy or arthrogryposis multiplex congenita may be at increased risk.
    • Previous anesthetics have been associated with fever in susceptible patients.

    Observation:

    • Althesin was administered to two patients with MH susceptibility, one with familial myopathy and another with arthrogryposis.
    • In one case, halothane was accidentally co-administered; in another, halothane was intentionally combined with Althesin.
    • No signs of malignant hyperthermia, such as fever, muscle rigidity, or elevated serum CPK, were observed in either patient.

    Findings:

    • Althesin administration did not trigger hyperpyrexia in MH-susceptible patients.

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  • Serum creatine phosphokinase (CPK) levels remained stable, indicating no muscle damage.
  • These clinical observations align with prior experimental and clinical evidence suggesting Althesin's protective effect against MH.

    • Implications:

    • Althesin demonstrates potential as a safe anesthetic option for individuals predisposed to malignant hyperthermia.
    • Further research may confirm Althesin's role in mitigating MH risk in vulnerable patient populations.
    • This supports the use of Althesin in anesthesiology for high-risk patients.