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Nasal spray bromocriptine: effects on serum prolactin in puerperal women
E Cicinelli1, D Petruzzi, G Ragno
1Department of Obstetrics and Gynecology, University of Bari, Italy.
Background:
The objective of this study was to investigate the effectiveness of a single nasal spray administration of 0.8 mg bromocriptine in reducing PRL serum levels.
Methods:
Eighteen physiologically hyperprolactemic women in the early days of puerperium were randomized to receive nasal bromocriptine or placebo; PRL serum levels were measured by RIA at 45, 30 and 15 minutes before the administration and after the following times: 15, 30, 45, 60, 120, 180, 240, 300, and 480 minutes.
Results:
After the administration of bromocriptine serum levels of PRL decreased rapidly; the reduction was statistically significant after 45 minutes. Four hours after the administration mean serum levels of PRL resulted in the normal range (< 20 micrograms/l); at the eighth hour the PRL levels were still normal. No one patient complained of any local or systemic side-effects.
Conclusion:
Nasal route seems to be an effective and probably safe administration route for bromocriptine.