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OK-432 therapy for lymphangiomas

R J Smith1, D K Burke, Y Sato

  • 1Department of Otolaryngology, University of Iowa, Iowa City, USA.

Archives of Otolaryngology--Head & Neck Surgery
|November 1, 1996
PubMed
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OK-432 sclerotherapy shows promise for treating macrocystic lymphangiomas. This treatment was effective in two cases, but not for microcystic types or venous malformations.

Area of Science:

  • Pediatric Surgery
  • Interventional Radiology
  • Oncology

Background:

  • Lymphangiomas are benign congenital vascular malformations.
  • Treatment options for lymphangiomas can be challenging.
  • Sclerotherapy is a potential therapeutic modality.

Purpose of the Study:

  • To evaluate the effectiveness of OK-432 sclerotherapy.
  • To assess outcomes in children with lymphangiomas.

Main Methods:

  • A nonrandomized trial was conducted at an academic tertiary referral center.
  • Six children with presumed lymphangiomas underwent fluoroscopically guided intervention.
  • Intervention involved cyst aspiration, cystography, and OK-432 injection.

Main Results:

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  • Complete response was observed in 2 cases of macrocystic lymphangioma.
  • No response was noted in 3 cases of microcystic lymphangioma.
  • One case of venous malformation showed no response.

Conclusions:

  • OK-432 sclerotherapy may be an effective treatment for macrocystic lymphangiomas.
  • Further research is warranted to explore its efficacy in other lymphangioma subtypes.