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Eosinophils negatively regulate eosinophilopoiesis by decreasing IL-5 levels
H Enokihara1, T Koike, Y Nakamura
1Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
International Archives of Allergy and Immunology
|January 1, 1996
Abstract:
The effect of mature eosinophils on eosinophilopoiesis was studied. Mature eosinophils decreased the interleukin-5 (IL-5) level after incubation with IL-5 and suppressed IL-5 release from non-adherent mononuclear cells. These findings suggest that eosinophils negatively regulate eosinophilopoiesis by decreasing the IL-5 level.