Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

TH2-type cytokines in asthma

A B Kay1

  • 1Imperial College School of Medicine, National Heart and Lung Institute, London, England.

Annals of the New York Academy of Sciences
|October 31, 1996
PubMed
Summary
This summary is machine-generated.

T-helper 2 (TH2) cells drive eosinophil inflammation in asthma, a key factor in chronic symptoms. While other cells contribute, TH2 cells play a central role in orchestrating this response.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunosuppression in Chronic Asthma.

International archives of allergy and immunology·2021
Same author

The early history of the eosinophil.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2014
Same author

Elevations in T-helper-2-initiating cytokines (interleukin-33, interleukin-25 and thymic stromal lymphopoietin) in lesional skin from chronic spontaneous ('idiopathic') urticaria.

The British journal of dermatology·2014
Same author

Calcitonin gene-related peptide and vascular endothelial growth factor are expressed in lesional but not uninvolved skin in chronic spontaneous urticaria.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2014
Same author

Elevations in vascular markers and eosinophils in chronic spontaneous urticarial weals with low-level persistence in uninvolved skin.

The British journal of dermatology·2014
Same author

Immunotherapy is allergen-specific: a double-blind trial of mite or timothy extract in mite and grass dual-allergic patients.

International archives of allergy and immunology·2012
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Cell Biology

Background:

  • Asthma pathogenesis involves eosinophil recruitment and activation, leading to airway inflammation and damage.
  • T-helper 2 (TH2) cytokines, including interleukin-5 (IL-5), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-3 (IL-3), are critical regulators of eosinophil function.
  • Eosinophils are considered key proinflammatory effector cells contributing to chronic asthma symptoms.

Purpose of the Study:

  • To elucidate the central role of TH2-type T cells in orchestrating eosinophil responses in asthma.
  • To explore the potential antigens driving asthmatic inflammation.
  • To clarify the relative contributions of T cell-mediated and IgE-mediated mechanisms in asthma.

Main Methods:

  • The study focuses on the immunological pathways and cellular interactions involved in asthma.

Related Experiment Videos

  • It reviews the known roles of various cytokines and cell types in eosinophil regulation.
  • The analysis considers the significance of antigen recognition by T cells and IgE-mediated responses.

    • Main Results:

    • TH2-type cytokines, IL-5, GM-CSF, and IL-3 are identified as key orchestrators of the eosinophil response in asthma.
    • TH2-type T cells are highlighted as central players due to their antigen recognition capabilities.
    • Allergens are proposed as potential driving antigens, with viral or epithelial antigens also considered.
    • IgE-mediated mechanisms are suggested to play a secondary role, primarily in acute symptoms of atopic asthma.

    Conclusions:

    • TH2-type T cells are central to the cell-mediated inflammatory process in chronic asthma.
    • Eosinophil-driven inflammation, orchestrated by TH2 cytokines, is a primary cause of persistent asthma symptoms.
    • While IgE contributes to acute symptoms, the underlying chronic inflammation is T cell-dependent.