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Cerebral oligodendrogliomas in children: an analysis of 15 cases
T Rizk1, C Mottolèse, E Bouffet
1Service de Neurochirurgie Pédiatrique, Hôpital Pierre Wertheimer, Lyon, France.
Insights
Pediatric cerebral oligodendrogliomas present differently based on symptoms. Epilepsy indicates a benign tumor with good survival, while intracranial hypertension suggests an anaplastic tumor with poor prognosis in children.
Area of Science:
- Pediatric neuro-oncology
- Neurosurgery
- Neuropathology
Background:
- Cerebral oligodendrogliomas are rare pediatric brain tumors.
- Understanding prognostic factors is crucial for treatment planning.
Purpose of the Study:
- To investigate the correlation between clinical presentation, histological grade, and survival outcomes in pediatric cerebral oligodendrogliomas.
Main Methods:
- Retrospective analysis of 15 children operated on for cerebral pure oligodendroglioma.
- Classification into two groups based on presenting symptoms: epilepsy or intracranial hypertension.
- Histological grading and survival data were analyzed.
Main Results:
- Group I (epilepsy, n=7) had all histologically benign tumors and remained alive after a median 72-month follow-up, with 2 experiencing recurrence but now disease-free.
- Group II (intracranial hypertension, n=8) predominantly had anaplastic tumors (7/8 cases).
- Despite aggressive treatment, 6 children in Group II died, with a median survival of 17 months.
Conclusions:
- Clinical presentation significantly correlates with histological grade and survival in pediatric oligodendrogliomas.
- Epilepsy as a presenting symptom suggests a favorable prognosis.
- Intracranial hypertension indicates a higher likelihood of anaplastic histology and poorer survival outcomes.
Abstract:
The cases of 15 children operated on for cerebral pure oligodendroglioma were studied. Two groups of children were distinguished. Group I children presented with epilepsy (7 cases); their tumor was histologically benign in all cases. These children are all alive after a median follow-up of 72 months: however, 2 of them presented with a local recurrence, which was operated on, and are actually disease-free. Group 2 children presented with intracranial hypertension (8 cases); the tumor was anaplastic in 7 cases. Despite postoperative radiotherapy and chemotherapy 6 children died; their median survival time was 17 months. The present series shows the existence of a clear correlation between clinical presentation, histological grading and survival in childhood cerebral oligodendrogliomas.