Related Experiment Videos
Adult moyamoya disease progressing from unilateral to bilateral involvement
H Wanifuchi1, M Takeshita, N Aoki
1Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical College.
Neurologia Medico-Chirurgica
|February 1, 1996
Summary
Serial angiography is crucial for adults with probable moyamoya disease presenting with ischemic stroke. This follow-up imaging can reveal disease progression to definite moyamoya disease, highlighting the need for careful monitoring.
Area of Science:
- Neurology
- Vascular Neurology
- Neuroimaging
Background:
- Moyamoya disease is a rare cerebrovascular disorder characterized by progressive stenosis of the internal carotid arteries and their branches.
- Diagnosis relies on specific angiographic findings, with classifications including "probable" and "definite" stages.
- Ischemic stroke is a common presenting symptom in adult moyamoya disease.
Observation:
- Two adult patients initially presented with "probable" moyamoya disease manifesting as ischemic stroke.
- Initial angiography revealed unilateral occlusive lesions.
- Follow-up angiography demonstrated the development of bilateral occlusive lesions, meeting the criteria for "definite" moyamoya disease.
Findings:
- Adult-onset moyamoya disease can progress from unilateral to bilateral involvement over time.
- "Probable" moyamoya disease in adults, especially with ischemic stroke, warrants serial angiographic follow-up.
- The progression observed underscores the dynamic nature of the disease process.
Implications:
- This case series emphasizes the importance of serial angiography in the diagnostic workup and management of adults with probable moyamoya disease.
- Early detection of disease progression can potentially guide timely therapeutic interventions.
- Further research into the natural history and progression patterns of adult moyamoya disease is warranted.