[The activation processes of T-lymphocytes and their regulatory subpopulations in patients with pulmonary tuberculosis]
Related Experiment Video
Updated: Aug 8, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
Abstract:
Immunophenotyping of lymphocytes by direct double-color immunofluorescence, investigation of metabolic activity of succinate dehydrogenase, alpha-glycerophosphate dehydrogenase, glucose-6-phosphate dehydrogenase, NAD- and NADP-diaphorases were performed in 77 tuberculous patients and 50 healthy donors. Activation of T-lymphocytes and their regulatory subpopulations is shown to depend on the extension of lung infiltration. At the same time, there were marked disorders in intracellular metabolism of peripheral blood lymphocytes. Close correlation exists between the activity of lymphocytic energy enzymes and the degree of expression on lymphocytes of receptors to interleukin-2, transferrin and HLA-DR-molecules. Cytochemical reactions for evaluation of blood lymphocyte energetic enzymes activity may be used in clinical practice for characterization of activation of T-lymphocytes and their regulatory subpopulations.
Related Concept Videos
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Tuberculosis

