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Disposition decomposition analysis for pharmacodynamic modeling of the link compartment

H Cheng1, W J Jusko

  • 1Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA.

Biopharmaceutics & Drug Disposition
|March 1, 1996
PubMed
Summary

A new disposition decomposition analysis (DDA) method models drug effects, calculating key parameters like mean transit time and biophase concentration. This approach enhances pharmacokinetic/pharmacodynamic modeling for better drug distribution analysis.

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