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Updated: Oct 11, 2026

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Reactive disulfide bonds in immunoglobulin G. A unique feature in serum proteins of different species
E Schauenstein1, K Schauenstein, F Dachs
1Institute of Biochemistry, University of Graz, Austria.
Abstract:
A reactive disulfide bond (SS)* was detected and characterized in IgG of humans, rats and mice by virtue of disulfide interchange with dithionitrobenzoate. (SS)* was found exclusively in human IgG1 and rat IgG2b. In human IgG1 (SS)* was identified as the upper one of the two interheavy bridges in the hinge, where it appears to take part in complement activation. The biological significance of (SS)* in IgG was underlined by the fact that no other serum proteins were found to exhibit a similar reactivity.
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