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Related Experiment Videos

Reduced decrease of peripheral vascular resistance during exercise in young type I diabetic patients

D Matthys1, M Craen, D De Wolf

  • 1Department of Pediatrics, University Hospital Gent, Belgium. dirk.matthys@rug.ac.be

Diabetes Care
|November 1, 1996
PubMed
Summary

Young type I diabetic patients show impaired vasodilator response during exercise, with higher blood pressure and vascular resistance compared to healthy individuals. This suggests altered cardiovascular regulation in diabetic adolescents.

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Area of Science:

  • Cardiovascular Physiology
  • Pediatric Endocrinology
  • Exercise Science

Background:

  • Peripheral vascular resistance normally decreases during dynamic exercise in healthy individuals.
  • Type I diabetes can affect cardiovascular function, even in normotensive adolescents.

Purpose of the Study:

  • To investigate blood pressure and peripheral vascular resistance responses to dynamic exercise in young, normotensive type I diabetic patients.
  • To compare these responses with age- and sex-matched healthy control subjects.

Main Methods:

  • Thirty adolescent type I diabetic patients (9-19 years) and 24 healthy controls underwent maximal exercise testing on a cycle ergometer.
  • Cardiac output was measured in a subset of 14 diabetic patients using CO2 rebreathing; peripheral vascular resistance was calculated.

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  • Diastolic blood pressure and peripheral vascular resistance were assessed at intermediate and peak exercise workloads.

    • Main Results:

    • Diabetic patients exhibited significantly higher diastolic blood pressure at intermediate (77 vs. 71 mmHg) and peak exercise (86 vs. 73 mmHg) compared to controls.
    • Peripheral vascular resistance was significantly elevated in diabetic patients at intermediate (17.0 vs. 12.6 mmHg.l-1.min-1.m-2) and peak exercise (16.3 vs. 11.4 mmHg.l-1.min-1.m-2).
    • No significant correlations were found between these responses and diabetes duration, age, or glycemic control.

    Conclusions:

    • Young, normotensive type I diabetic patients demonstrate a reduced vasodilator response during dynamic exercise.
    • This impaired vascular response is characterized by elevated peripheral vascular resistance and blood pressure during exertion.