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Cardiovascular adverse effects of antimicrobials in complex surgical cases
M Kuenneke1, B Stinner, I Celik
1Institute of Theoretical Surgery, Philipps-University, Marburg, Germany.
The European Journal of Surgery. Supplement. : = Acta Chirurgica. Supplement
|January 1, 1996
Abstract:
Previously undescribed adverse effects of antibiotics on the cardiovascular system were described in complex surgical cases. Hypotension, bradycardia and tachycardia were seen in a randomised clinical trial, and confirmed in a randomised experiment with piglets, and in a study with isolated vascular tissue that was exposed simultaneously to antibiotics, endotoxin, and later on histamine at histamine H1-receptors. These findings may influence indications and duration for antimicrobial therapy, and support the concept of "minimal" postoperative antibiotic therapy in emergency abdominal operations.