Relationship between acid secretory activity and gastroduodenal migrating motor complex

Area of Science:

• Gastroenterology
• Physiology

Background:

• Gastric acid secretion and motor activity exhibit synchronized rhythms during the interdigestive period.
• The precise relationship between these cyclic activities requires further investigation.

Purpose of the Study:

• To investigate the relationship between cyclic acid secretory activity and gastroduodenal motor activity during the interdigestive period.

Main Methods:

• Recorded interdigestive gastroduodenal motor activity and intragastric pH in 9 healthy subjects using manometry and pH-metry.
• Administered 20 mg intravenous omeprazole 30 minutes after the second phase III of the Migrating Motor Complex (MMC).

Main Results:

• Omeprazole administration triggered a premature phase III of the Migrating Motor Complex (MMC).
• The motor activity preceding the induced phase III was comparable to spontaneous phase III.
• Intragastric pH significantly increased following omeprazole administration and before the induced phase III.

Conclusions:

• Inhibition of gastric acid secretion by omeprazole is followed by the appearance of a typical gastroduodenal phase III.
• This suggests that acid secretory activity influences the motor activity of the gastroduodenal tract.