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Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
A Romanian contribution to the epidemiology and prevention of cardiovascular diseases
1N. Gh. Lupu Institute of Internal Medicine, Bucharest, Romania.
Insights
This study highlights 35 years of research on cardiovascular disease epidemiology and prevention, focusing on diet
Area of Science:
- Cardiovascular Epidemiology
- Preventive Cardiology
- Atherosclerosis Pathogenesis
Background:
- The
- N. Gh. Lupu
- Institute of Internal Medicine has conducted extensive research over 35 years.
- Research focused on cardiovascular diseases, particularly atherosclerosis and coronary heart disease.
- Studies investigated specific populations like fishermen and lumberjacks to understand dietary impacts.
Purpose of the Study:
- To present the scientific activity in cardiovascular disease epidemiology and prevention.
- To investigate the role of dietary fat saturation in atherosclerosis.
- To conduct a long-term primary prevention trial for coronary heart disease.
Main Methods:
- Epidemiological surveys in the Danube Delta and Gurghiu Valley.
- Analysis of dietary fat saturation in relation to atherosclerosis.
- Longitudinal primary prevention trial (Bucharest Multifactorial Prevention Trial) involving 10,000 middle-aged men.
- Analysis of over one hundred published works.
Main Results:
- Identified specific populations with distinct dietary patterns for epidemiological study.
- Initiated a 25-year follow-up study on coronary heart disease prevention.
- Compiled extensive research data from over a hundred publications.
Conclusions:
- Established a significant body of work in cardiovascular epidemiology and prevention.
- Provided insights into the role of diet in cardiovascular disease pathogenesis.
- Demonstrated the feasibility and importance of long-term prevention trials.
Abstract:
The paper presents the scientific activity developed in the last thirty-five years by a team of cardiologists, internists, biologists, biochemists, biomathematicians and computer specialists in the "N. Gh. Lupu" Institute of Internal Medicine (Bucharest) in the field of epidemiology and prevention of cardiovascular diseases. The main places of the epidemiological surveys were the Danube Delta (among fishermen) and the Gurghiu Valley (in the Eastern Carpathians) among lumberjacks, two collectivities selected by the nature of their diet in order to prove the role of fat saturation in the pathogenesis of atherosclerosis. In 1971 this team began one of the long-lasting projects of primary prevention of coronary heart disease (on 10,000 middle-aged men) which is now at its 25-year follow-up ("The Bucharest Multifactorial Prevention Trial of Coronary Heart Disease"). The analysis of this activity refers to more than hundred works of the team.
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