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Related Experiment Videos

Acute bioeffects of electromagnetic lithotripsy

O Atahan1, T Alkibay, U Karaoğlan

  • 1Urologic Clinics of TCDD, Ankara Hospital, Türkiye.

Scandinavian Journal of Urology and Nephrology
|August 1, 1996
PubMed
Summary

Extracorporeal shock wave lithotripsy (ESWL) causes temporary kidney damage, including altered protein excretion and reduced creatinine clearance. Most functional and morphological changes resolve within 30 days post-treatment.

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Area of Science:

  • Nephrology
  • Urology
  • Medical Imaging

Background:

  • Kidney stones are a common ailment requiring treatment.
  • Extracorporeal shock wave lithotripsy (ESWL) is a primary modality for kidney stone management.
  • Assessing the acute renal impact of ESWL is crucial for patient care.

Purpose of the Study:

  • To evaluate the acute morphologic and functional effects of ESWL on kidneys.
  • To determine the transient nature of these renal changes post-ESWL.

Main Methods:

  • Prospective study involving 42 patients with unilateral kidney stones undergoing ESWL.
  • Collection of 24-hour urine and blood samples pre-ESWL, day after, and 30 days after.
  • Radiological assessments including excretory urography, ultrasonography, and CT-scanning at specified intervals.

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  • Analysis of urinary protein, glycosaminoglycan, immunoglobulin G excretion, and creatinine clearance.

    • Main Results:

    • Significant elevations in urinary protein, glycosaminoglycan, and immunoglobulin G post-ESWL, normalizing by 30 days.
    • Temporary decrease in creatinine clearance, with recovery within one month.
    • Radiological abnormalities detected in a significant percentage of kidneys immediately after ESWL, with most resolving by 30 days.
    • No correlation found between patient demographics/stone characteristics and observed changes.

    Conclusions:

    • Electromagnetic ESWL induces acute, transient renal functional changes that resolve within a month.
    • While functional recovery is complete, some morphologic renal changes may persist beyond 30 days post-ESWL.
    • ESWL is generally safe, with most acute renal effects being temporary.