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LC50 of 2-bromopropane

H Y Kim1, Y H Chung, K H Yi

  • 1Department of Industrial Toxicology, Industrial Health Research Institute Korea Industrial Safety Corporation, Bupyung-gu, Inchon, Korea.

Industrial Health
|January 1, 1996
PubMed
Summary
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The lethal concentration 50 (LC50) for 2-bromopropane in mice was determined to be 31,171 ppm. This study reexamined the toxicity of 2-bromopropane following standardized OECD guidelines.

Area of Science:

  • Toxicology
  • Occupational Health
  • Chemical Safety

Background:

  • 2-bromopropane is a chemical with potential occupational exposure risks.
  • Accurate toxicity data is crucial for risk assessment and safety protocols.

Purpose of the Study:

  • To reexamine the LC50 of 2-bromopropane in ICR mice.
  • To adhere to OECD guidelines for standardized toxicity testing.

Main Methods:

  • Inhalation exposure of mice (3 males, 3 females) to five concentrations of 2-bromopropane for 4 hours.
  • Observation of surviving and deceased animals for 14 days post-exposure.
  • Calculation of LC50 using a dose-mortality curve at a 95% confidence level.

Main Results:

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  • The determined LC50 for 2-bromopropane was 31,171 ppm.
  • The lowest lethal concentration (LLC) was below 29,528 ppm.
  • The lethal concentration for 100% mortality (LC100) was above 32,905 ppm.

    • Conclusions:

    • The reexamined LC50 provides updated toxicity data for 2-bromopropane.
    • Findings support the establishment of safety limits for handling 2-bromopropane.
    • The study confirms the acute inhalation toxicity of 2-bromopropane in mice.