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Splenectomy for haematological disease

J S Jameson1, W M Thomas, S Dawson

  • 1Department of Surgery, Leicester Royal Infirmary, UK.

Journal of the Royal College of Surgeons of Edinburgh
|October 1, 1996
PubMed
Summary
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Splenectomy use in hematological diseases has decreased, with idiopathic thrombocytopenic purpura becoming the primary indication. Despite fewer procedures, splenectomy remains largely successful in treating patients.

Area of Science:

  • Hematology
  • Surgical Oncology

Background:

  • The role of splenectomy in managing hematological disorders is evolving.
  • Previous trends indicated a consistent utilization of splenectomy for various blood-related conditions.

Purpose of the Study:

  • To analyze the changing indications and outcomes of splenectomy in hematological diseases.
  • To compare splenectomy practices and results over two distinct 7-year periods.

Main Methods:

  • A retrospective analysis of 64 patients who underwent splenectomy over a 7-year period.
  • Comparison of patient data and splenectomy rates with a preceding 7-year timeframe.

Main Results:

  • Idiopathic thrombocytopenic purpura was the leading indication for splenectomy.

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  • A 40% reduction in splenectomy procedures was observed, despite an increase in overall hematological disease patient numbers.
  • Post-operative mortality was low (1 death), with a morbidity rate of 63% and an 80% success rate for splenectomy.

    • Conclusions:

    • The declining use of splenectomy for Hodgkin's disease and auto-immune hemolytic anemia significantly impacted overall splenectomy rates.
    • Splenectomy remains an effective treatment for specific hematological conditions, particularly idiopathic thrombocytopenic purpura.