Serum alkaline phosphatase: normal values by sex and age

Area of Science:

• Biochemistry
• Clinical Chemistry
• Enzymology

Background:

• Serum alkaline phosphatase is a key enzyme with diagnostic relevance.
• Previous studies had limited sample sizes for establishing normal ranges.
• Enzyme activity is known to be influenced by physiological factors.

Purpose of the Study:

• To determine the normal range of serum alkaline phosphatase activity.
• To validate a standardized measurement method for clinical use.
• To investigate the influence of demographic factors on enzyme levels.

Main Methods:

• Serum alkaline phosphatase activity was measured using the method by Hausamen et al.
• A large, well-defined sample population was analyzed.
• Statistical analysis included stratification by age and sex.

Main Results:

• The normal range of serum alkaline phosphatase activity was established using percentiles.
• Age and sex were identified as significant factors influencing enzyme activity.
• No statistically significant effect of blood type on enzyme activity was found.

Conclusions:

• A reliable normal range for serum alkaline phosphatase activity has been determined.
• The findings support the use of the standardized method for clinical diagnostics.
• Understanding demographic influences enhances the interpretation of enzyme activity results.