Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changed serum trace element profile in Down's syndrome

J Kadrabová1, A Madáric, M Sustrová

  • 1Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.

Biological Trace Element Research
|September 1, 1996
PubMed
Summary

Serum zinc and selenium are lower, while copper is higher in individuals with Down

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Danger of very high HDL levels.

Bratislavske lekarske listy·2017
Same author

Impact of interleukin 13 (IL13) genetic polymorphism Arg130Gln on total serum immunoglobulin (IgE) levels and interferon (IFN)-γ gene expression.

Clinical and experimental immunology·2017
Same author

Risk of statin therapy in elderly.

Bratislavske lekarske listy·2016
Same author

Deficiency of vitamin D and vitamin C in the pathogenesis of bronchial asthma.

Bratislavske lekarske listy·2016
Same author

New data on harmful effects of trans-fatty acids.

Bratislavske lekarske listy·2016
Same author

How far down to push the LDL cholesterol? PCSK9 where statins fail.

Bratislavske lekarske listy·2016

Area of Science:

  • Biochemistry
  • Human Genetics
  • Nutritional Science

Background:

  • Antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx) are crucial for cellular protection.
  • These enzymes' function is significantly altered in Down's syndrome (trisomy 21).
  • Microtrace elements zinc, copper, and selenium, along with magnesium, act as essential cofactors for these antioxidant enzymes.

Purpose of the Study:

  • To investigate serum levels of key trace elements (zinc, copper, selenium) and magnesium in individuals with Down's syndrome (DS).
  • To compare these levels with age- and sex-matched healthy controls.
  • To understand the relationship between these elements and the modified antioxidant enzyme activity in DS.

Main Methods:

  • Serum samples were collected from 16 subjects diagnosed with Down's syndrome.
  • Serum samples were also collected from a control group of age- and sex-matched healthy individuals.
  • Serum concentrations of zinc, copper, selenium, and magnesium were quantified using appropriate analytical techniques.

Main Results:

  • Serum zinc levels were significantly decreased in individuals with Down's syndrome compared to controls.
  • Serum selenium levels were also found to be significantly lower in the DS group.
  • Conversely, serum copper levels were significantly elevated in subjects with Down's syndrome.
  • The copper/zinc ratio showed a marked increase (40%) in the DS group.
  • No significant differences in serum magnesium levels were observed between the DS and control groups.

Conclusions:

  • Down's syndrome is associated with altered serum levels of essential trace elements, specifically lower zinc and selenium, and higher copper.
  • The increased copper/zinc ratio in DS may indicate oxidative stress or altered metabolic pathways.
  • These findings highlight potential nutritional imbalances in individuals with Down's syndrome that could impact antioxidant defense mechanisms.

Related Experiment Videos