Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The stress activated protein kinase pathway

J R Woodgett1, J Avruch, J Kyriakis

  • 1Ontario Cancer Institute, Toronto, Canada.

Cancer Surveys
|January 1, 1996
PubMed
Summary

Stress-activated protein kinases (SAPKs) transmit cellular injury signals to the nucleus, influencing gene expression and growth arrest. Understanding SAPK pathways may lead to new diagnostic and therapeutic strategies for cell injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function.

FASEB bioAdvances·2019
Same author

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function.

Nature communications·2019
Same author

Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.

Oncogene·2014
Same author

Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment.

Cell death & disease·2014
Same author

GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span.

Endocrinology·2013
Same author

Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner.

Oncogene·2013

Area of Science:

  • Cellular biology
  • Molecular signaling pathways
  • Stress response mechanisms

Background:

  • Stress-activated protein kinases (SAPKs) are crucial signaling molecules.
  • These pathways transmit cellular insults to the nucleus, affecting gene expression.
  • SAPKs are activated by various agents that harm cell growth.

Purpose of the Study:

  • To elucidate the physiological functions of SAPK pathways.
  • To explore the role of SAPKs in cellular injury and gene expression.
  • To identify potential diagnostic and therapeutic applications related to SAPKs.

Main Methods:

  • Analysis of protein kinase cascades within the SAPK pathway.
  • Investigating the activation of SAPKs by diverse cellular stressors.
  • Comparing SAPK pathway function with the related Mitogen-Activated Protein Kinase (MAPK) pathway.

Main Results:

  • SAPKs are not required for cell proliferation (mitogenesis).
  • SAPKs induce cell growth arrest in response to cellular stress.
  • The pathway is modulated by inflammatory cytokines, reperfusion injury, and chemotherapeutics.

Conclusions:

  • SAPKs serve as critical mediators of cellular stress responses.
  • Elucidating SAPK functions offers potential for novel diagnostic and therapeutic interventions.
  • Further research into SAPK pathways is warranted for clinical applications.

Related Experiment Videos