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Updated: Aug 1, 2026

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Published on: September 24, 2020
Trifluoperazine is more effective than chlorpromazine in releasing oxygen from haemoglobin and myoglobin
J Bhattacharyya1, M Bhattacharyya, A S Chakraborti
1Department of Biophysics, Molecular Biology & Genetics, University of Calcutta, India.
Abstract:
The extent of oxygen release from two heme proteins, haemoglobin and myoglobin have been studied in the presence of trifluoperazine and chlorpromazine (5-1000 microM). At a molar ratio (drug:protein) of 1.5, the release of oxygen from haemoglobin was 4 and 15% in the presence of chlorpromazine and trifluoperazine respectively, while from myoglobin the corresponding values were 20 and 40%. The findings were attributed to the greater extent of local conformational change around tryptophan moieties of each of the proteins induced by trifluoperazine.
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